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XXVII CONGRESSO PORTUGUÊS DE ATEROSCLEROSE


XXVII CONGRESSO PORTUGUÊS DE ATEROSCLEROSE

VIII CURSO AVANÇADO DE LIPIDOLOGIA 2019

87th EAS Congress


87th EAS Congress

Hipercolesterolemia Familiar (HF)

 

Materiais informativos

Hipercolesterolemia Familiar (HF)

Desenvolvidos pelo “International FH Paediatric Register”.

Uma cortesia do Grupo de Investigação Cardiovascular do INSA para chegar as famílias com crianças com FH para que melhor compreendam a sua doença e vivam melhor com ela.

Foram desenvolvidos para idades diferentes com conteúdos adaptados:

quinta, 28 fevereiro 2019 12:55

Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mildcognitive impairment and dementia in later life: The atherosclerosis risk in communities study

Knopman DS1, Gottesman RF2, Sharrett AR3, Tapia AL4, DavisThomas S4, Windham BG5, Coker L6, Schneider ALC2, Alonso A7, Coresh J3, Albert MS2, Mosley TH Jr5.

Abstract

INTRODUCTION:

The interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment(MCI) and dementia (DEM) is not well understood.

METHODS:

In the Atherosclerosis Risk in Communities Study, cardiovascular risk factors and cognition were assessed in midlife, ages 45-64 years. In 2011-2013, 20-25 years later, all consenting Atherosclerosis Risk in Communities participants underwent a cognitive and neurological evaluation and were given adjudicated diagnoses of cognitively normal, MCI, or DEM.

RESULTS:

In 5995 participants with complete covariate data, midlife diabetes, hypertension, obesity, and hypercholesterolemia were associated with late-life MCI and DEM. Low midlife cognition function was also associated with greater likelihood of late-life MCI or DEM. Both midlife vascular risk factors and midlife cognitive function remained associated with later life MCI or DEM when both were in the model.

DISCUSSION:

Later life MCI and DEM were independently associated with midlife vascular risk factors and midlife cognition.

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1 Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: Este endereço de email está protegido contra piratas. Necessita ativar o JavaScript para o visualizar..

2 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

3 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

4 Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

5 Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

6 Division of Public Health Sciences, School of Medicine, Wake Forest University, Winston-Salem, NC, USA.

7 Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.