Abstract
INTRODUCTION:
The interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment(MCI) and dementia (DEM) is not well understood.
METHODS:
In the Atherosclerosis Risk in Communities Study, cardiovascular risk factors and cognition were assessed in midlife, ages 45-64 years. In 2011-2013, 20-25 years later, all consenting Atherosclerosis Risk in Communities participants underwent a cognitive and neurological evaluation and were given adjudicated diagnoses of cognitively normal, MCI, or DEM.
RESULTS:
In 5995 participants with complete covariate data, midlife diabetes, hypertension, obesity, and hypercholesterolemia were associated with late-life MCI and DEM. Low midlife cognition function was also associated with greater likelihood of late-life MCI or DEM. Both midlife vascular risk factors and midlife cognitive function remained associated with later life MCI or DEM when both were in the model.
DISCUSSION:
Later life MCI and DEM were independently associated with midlife vascular risk factors and midlife cognition.
1 Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: Este endereço de email está protegido contra piratas. Necessita ativar o JavaScript para o visualizar..
2 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
3 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
4 Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
5 Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
6 Division of Public Health Sciences, School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
7 Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
