Área de Sócio

30.º aniversário

Jornal do Congresso

30.º Congresso Português de Aterosclerose, n.º1


PCS Academy

Hipercolesterolemia Familiar (HF)


Materiais informativos

Hipercolesterolemia Familiar (HF)

Desenvolvidos pelo “International FH Paediatric Register”.

Uma cortesia do Grupo de Investigação Cardiovascular do INSA para chegar as famílias com crianças com FH para que melhor compreendam a sua doença e vivam melhor com ela.

Foram desenvolvidos para idades diferentes com conteúdos adaptados:

terça-feira, 01 abril 2014 10:36

Eighteen-year trends in stroke mortality and the prognostic influence of comorbidity

To examine 18-year trends in short-term and long-term stroke mortality and the prognostic influence of comorbidity.

Schmidt M(1), Jacobsen JB, Johnsen SP, Bøtker HE, Sørensen HT.

OBJECTIVES: To examine 18-year trends in short-term and long-term stroke mortality and the prognostic influence of comorbidity.

METHODS: We conducted a nationwide population-based cohort study. Using the Danish National Registry of Patients, covering all Danish hospitals, we identified all 219,354 patients with a first-time hospitalization for stroke during 1994-2011. We computed standardized 30-day, 1-year, and 5-year mortality by sex. Comorbidity categories were defined by Charlson Comorbidity Index scores of 0 (none), 1 (moderate), 2 (severe), and 3 or more (very severe). Calendar periods of diagnosis (1994-1998, 1999-2003, 2004-2008, and 2009-2011) and comorbidity categories were compared by means of mortality rate ratios based on Cox regression.

RESULTS: Over time, the 30-day mortality rate ratio adjusted for age, sex, and comorbidity decreased by approximately 45% for ischemic stroke (standardized risk decreased from 17.2% in 1994-1998 to 10.6% in 2009-2011) and by 35% for intracerebral hemorrhage (from 43.2% to 33.8%). The absolute mortality reduction occurred for all levels of comorbidity. Five-year mortality risk decreased from 56.4% in 1994-1998 to 46.1% in 2004-2008 for ischemic stroke and from 66.1% to 61.0% for intracerebral hemorrhage. Comparing very severe comorbidity with no comorbidity, 30-day and 5-year mortality rate ratios were both approximately 2.5-fold increased for ischemic stroke and 1.7-fold increased for intracerebral hemorrhage.

: Short- and long-term mortality improved considerably between 1994 and 2011 for all types of stroke. Short-term mortality improved regardless of comorbidity burden. However, comorbidity burden was a strong prognostic factor for both short- and long-term mortality.


(1) From the Departments of Clinical Epidemiology (M.S., J.B.J., S.P.J., H.T.S.) and Cardiology (M.S., H.E.B.), Aarhus University Hospital, Denmark.

PMID: 24363134 [PubMed - indexed for MEDLINE]

. Neurology. 2014 Jan 28;82(4):340-50. doi: 10.1212/WNL.0000000000000062. Epub 2013 Dec 20.